cas 53123-88-9 Rapamycin for Immunosuppressive

Quick Details Port: shanghai Payment Terms: L/C,D/A,D/P,T/T,Western Union,MoneyGram Supply Ability: 10 Ton/Tons per Month Other Names: Rapamycin Form: solution Refractive index: 1.5280 (estimate) Grade Standard: Medicine Grade Color: colorless to yellow Boiling point: 799.83°C (rough estimate) Purity: 99% Density: 1.0352 (rough estimate) Vapor Pressure: 0.56 hPa ( 20 °C) CAS No.: 53123-88-9 Type: Immune Function Agents Storage: -20°C Specific rotation: D25 -58.2° (methanol) EINECS No.: 610-965-5 MF: C51H79NO13 Flash point: 87 °C Melting point: 183-185°C Packaging Detail: as customers requirements Product Description DescriptionRapamycin is a member of the macrolide immunosuppressant family and a FRAP inhibitor. Rapamycin exhibits binding and inhibitory actions to the FK506 binding protein (FKBP5) proline rotamase via simultaneous binding by FKBP12 and FRAP. FRAP (RAFT1) proteins exhibit homology to PI 4- and PI 3-kinases, which have PI 4-kinase and autophosphorylating activities.The rapamycin/FKBP complex does not inhibit the FRAP PI 4-kinase activity, but does inhibit FRAP autophosphorylation. Rapamycin is unique in its ability to inhibit lymphokine induced cell proliferation at the G1 and S phase as well as an irreversible cellular arrest at the G1 phase in S. cerevisiae cells. It also exhibits selective signal blocking leading to the activation of p70/85 S6 kinase, which is potentially due […]